Relevant sirtuin publications

A PubMed search for “sirtuin” yields nearly 2000 publications.

The numbers of sirtuin related publication has increased

 What we are providing here is a curated selection of reports with relevance to Evrys Bio’s proprietary SIRT2 inhibitors follows.

Sirtuins regulate viral replication

SIRT control of viral growth is conserved from bacteria to humans.

Anti-viral activities of sirtuin 2 inhibitors

SIRT2 inhibitors block replication and spread of multiple RNA and DNA viral pathogens.

Anti-microbial activities of sirtuin 2 inhibitors

SIRT2 inhibitors block replication of multiple intracellular microbial pathogens.

Anti-cancer activities of sirtuin 2 inhibitors

SIRT2 inhibitors block cancer cell growth and activate T cells in the tumor microenvironment.

(Cell Metab. 2020 Sep 1;32(3):420-436.e12. doi: 10.1016/j.cmet.2020.07.008. Epub 2020 Aug 7. PMID: 32768387)

Sirtuin 2-null mice predict that SIRT2 inhibitors will be well tolerated